![AffiAB® Anti-Hu CD117 PE [104D2]](/web/image/product.product/83031/image_1024/%5BAFG-EXB-1532%5D%20AffiAB%C2%AE%20Anti-Hu%20CD117%20PE%20%5B104D2%5D?unique=d31c23b)
Overview
CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.
Specificity:
The mouse monoclonal antibody 104D2 detects extracellular part of CD117 / c-Kit protooncogen.
Antigen
CD117
Clone
104D2
Species Reactivity
Non-human primates, Human, Cow
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
MOLM-1 megakaryocytic cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide