![AffiAB® Anti-Hu CD34 PE [QBEnd-10]](/web/image/product.product/83020/image_1024/%5BAFG-EXB-1521%5D%20AffiAB%C2%AE%20Anti-Hu%20CD34%20PE%20%5BQBEnd-10%5D?unique=d31c23b)
Overview
CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
Specificity:
The antibody QBEnd-10 reacts with an extracellular class II epitope on CD34, a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. This antibody has been also used as an endothelial marker.
Antigen
CD34
Clone
QBEnd-10
Species Reactivity
Non-human primates, Human
Negative Species
Dog, Sheep, Rat, Cow
Isotype
Mouse IgG1
Immunogen
Human endothelial vesicles
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide