![AffiAB® Anti-Hu CD261 PE [DR-4-02]](/web/image/product.product/82981/image_1024/%5BAFG-EXB-1482%5D%20AffiAB%C2%AE%20Anti-Hu%20CD261%20PE%20%5BDR-4-02%5D?unique=d31c23b)
Overview
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor) .
Specificity:
The mouse monoclonal antibody DR-4-02 recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Antigen
CD261
Clone
DR-4-02
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide