![AffiAB® Anti-NTAL PE [NAP-07]](/web/image/product.product/82976/image_1024/%5BAFG-EXB-1477%5D%20AffiAB%C2%AE%20Anti-NTAL%20PE%20%5BNAP-07%5D?unique=0daa593)
Overview
NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Specificity:
The antibody NAP-07 reacts with an intracellular epitope of Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B lymphocytes, NK cells and myeloid cells.
Antigen
NTAL
Clone
NAP-07
Species Reactivity
Human, Mouse
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Recombinant cytoplasmic domain (aa 91-243) of human NTAL.
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide