AffiAB® Anti-Hu CD253 PE [2E5]

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CAT# AFG-EXB-1459
Size: 100 Tests

$ 281.00 281.0 USD $ 281.00

$ 281.00

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Overview

Human CD253 / TRAIL (TNF-related apoptosis inducing ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2) .

Specificity:

The antibody 2E5 reacts with an extracellular epitope within C-terminal half of TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.

Antigen

CD253

Clone

2E5

Species Reactivity

Human

Negative Species

Mouse

Isotype

Mouse IgG1

Immunogen

Recombinant soluble fragment (aa 95-281) of human TRAIL.

Application

FC (QC tested)

Regulatory status

RUO

Concentration

0.1 mg/ml

Format

Storage / Stability

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Storage Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide