![AffiAB® Anti-Ikaros PE [4E9]](/web/image/product.product/82883/image_1024/%5BAFG-EXB-1384%5D%20AffiAB%C2%AE%20Anti-Ikaros%20PE%20%5B4E9%5D?unique=0daa593)
Overview
Ikaros, also known as IKZF1 (Ikaros family zinc finger protein 1) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Helios. Ikaros forms homo- and heterodimers with these proteins and functions predominantly in early hematopoietic development. Expression of Ikaros, Aiolos and Helios is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Disruption of Ikaros leads to T and B cell leukemias.
Specificity:
The mouse monoclonal antibody 4E9 recognizes Ikaros, a transcription factor (intracellular antigen) expressed broadly in hematopoietic progenitors and serving as a key regulator of lymphopoiesis.
Antigen
Ikaros
Clone
4E9
Species Reactivity
Mouse, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Recombinant human Ikaros (C-terminal part)
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide