![AffiAB® Anti-Hu CD170 PE [1A5]](/web/image/product.product/82880/image_1024/%5BAFG-EXB-1381%5D%20AffiAB%C2%AE%20Anti-Hu%20CD170%20PE%20%5B1A5%5D?unique=d31c23b)
Overview
CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs) . CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2, 3- and alpha2, 6-linked sialic acid ligands, e.g. on glycophorin A (CD235a) . Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.
Specificity:
The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Antigen
CD170
Clone
1A5
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide