![AffiAB® Anti-Hu CD70 PE [Ki-24]](/web/image/product.product/82878/image_1024/%5BAFG-EXB-1379%5D%20AffiAB%C2%AE%20Anti-Hu%20CD70%20PE%20%5BKi-24%5D?unique=d31c23b)
Overview
CD70, also known as TNFSF7 or CD27L, is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.
Specificity:
The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
Antigen
CD70
Clone
Ki-24
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG3 kappa
Immunogen
human L428 cell line
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide