![AffiAB® Anti-Hu CD102 PE [CBR-IC2/2]](/web/image/product.product/82872/image_1024/%5BAFG-EXB-1373%5D%20AffiAB%C2%AE%20Anti-Hu%20CD102%20PE%20%5BCBR-IC2-2%5D?unique=d31c23b)
Overview
CD102 / ICAM-2 (intracellular cell adhesion molecule-2), a counter receptor of LFA-1 (CD11a/CD18), is a transmembrane glycoprotein with two extracellular IgC-like domains and intracellular C-terminal tail. It is involved in lymphocyte recirculation and homing to the sites of inflammation. Through interaction with integrins it provides to the immune cells costimulatory signals. Expression of CD102 on blood cells (lymphocytes, monocytes, thrombocytes) is lower than on endothelium and follicular dendritic cells. CD102 levels are upregulated in lymph nodes with malignant infiltration.
Specificity:
The mouse monoclonal antibody CBR-IC2/2 recognizes an extracellular epitope of CD102 (ICAM-2), an approximately 55 kDa type I transmembrane glycoprotein expressed mainly on vascular endothelial cells and folicular dendritic cells, in lower amount on lymphocytes, monocytes and platelets.
Antigen
CD102
Clone
CBR-IC2/2
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a
Immunogen
Human CD102 cDNA transfected COS cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide