![AffiAB® Anti-Hu CD49c PE [ASC-1]](/web/image/product.product/82862/image_1024/%5BAFG-EXB-1363%5D%20AffiAB%C2%AE%20Anti-Hu%20CD49c%20PE%20%5BASC-1%5D?unique=d31c23b)
Overview
CD49c / Integrin alpha 3 is a type I transmembrane glycoprotein proteolytically cleaved into two disulfide linked chains. It noncovalently associates with CD29 (integrin beta 1) to form the VLA-3 complex, an adhesion receptor for extracellular matrix components (fibronectin, laminin 1, laminin 5, entactin, and collagen) . It is expressed on adherent cells, mainly on fibroblasts, epithelial cells and endothelial cells.
Specificity:
The mouse monoclonal antibody ASC-1 recognizes an extracellular epitope of CD49c (integrin alpha 3), a transmembrane glycoprotein composed of disulfide linked 125 kDa and 30 kDa chains, and expressed on adherent cell lines and to a lesser extent on T and B cells and monocytes.
Antigen
CD49c
Clone
ASC-1
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
Human SSC-9 cell line (squamous cell carcinoma)
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
PE
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide