![AffiAB® Anti-Hu CD100 FITC [133-1C6]](/web/image/product.product/82829/image_1024/%5BAFG-EXB-1330%5D%20AffiAB%C2%AE%20Anti-Hu%20CD100%20FITC%20%5B133-1C6%5D?unique=d31c23b)
Overview
CD100, also known as semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.
Specificity:
The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100, an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes, NK cells, monocytes/macrophages and granulocytes, but also on some non-hematopoietic cells.
Antigen
CD100
Clone
133-1C6
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgM
Immunogen
PHA stimulated human PBL
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing Tris buffered saline (TBS) , pH 8.0, 15 mM sodium azide