![AffiAB® Anti-Hu CD68 FITC [Y1/82A]](/web/image/product.product/82826/image_1024/%5BAFG-EXB-1327%5D%20AffiAB%C2%AE%20Anti-Hu%20CD68%20FITC%20%5BY1-82A%5D?unique=d31c23b)
Overview
CD68 (also known as LAMP4 or SCARD1) is a 110 kDa type I transmembrane glycoprotein of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and the scavenger receptor family. Although CD68 primarily localizes to lysosomes and endosomes, its fraction circulates to the cell surface. By the heavily glycosylated extracellular domain CD68 binds to tissue- and organ-specific lectins or selectins. It is expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells, but also e.g. in a proportion of epithelial tumours (diagnosis of poorly differentiated neoplasms) .
Specificity:
The mouse monoclonal antibody Y1/82A recognizes CD68 (LAMP4), a 110 kDa glycoprotein expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells.
Antigen
CD68
Clone
Y1/82A
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
Lysosomal contents of lung macrophages
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide