![AffiAB® Anti-Ms CD2 FITC [RM2-5]](/web/image/product.product/82819/image_1024/%5BAFG-EXB-1320%5D%20AffiAB%C2%AE%20Anti-Ms%20CD2%20FITC%20%5BRM2-5%5D?unique=d31c23b)
Overview
CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
Specificity:
The rat monoclonal antibody RM2-5 recognizes an extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.
Antigen
CD2
Clone
RM2-5
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Rat IgG2b lambda
Immunogen
murine thymocytes
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide