![AffiAB® Anti-Ms CD45R FITC [RA3-6B2]](/web/image/product.product/82818/image_1024/%5BAFG-EXB-1319%5D%20AffiAB%C2%AE%20Anti-Ms%20CD45R%20FITC%20%5BRA3-6B2%5D?unique=d31c23b)
Overview
CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Specificity:
The rat monoclonal antibody RA3-6B2 recognizes an extracellular epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells. T cells detected by this antibody are supposed to be in activated state.
Antigen
CD45R
Clone
RA3-6B2
Species Reactivity
Cat, Mouse, Human
Negative Species
N/A
Isotype
Rat IgG2a kappa
Immunogen
Abelson murine leukemia virus-induced pre-B tumor cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.5 mg/ml
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide