![AffiAB® Anti-Hu CD35 FITC [E11]](/web/image/product.product/82816/image_1024/%5BAFG-EXB-1317%5D%20AffiAB%C2%AE%20Anti-Hu%20CD35%20FITC%20%5BE11%5D?unique=d31c23b)
Overview
CD35 (complement receptor 1, CR1) is a monomeric multiple modular cell surface glycoprotein which serves as receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. It is expressed mainly on the surface of granulocytes, monocytes, erythrocytes, B cells and folicular dendritic cells. Besides its role in complement cascade, CD35 is involved in blocking BCR-induced proliferation and the differentiation of B cells to plasmablasts and their Ig production.
Specificity:
The mouse monoclonal antibody E11 recognizes an extracellular epitope of CD35 (CR1), a type I transmembrane glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes.
Antigen
CD35
Clone
E11
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Acute monocytic leukemia cells and normal blood monocytes
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide