![AffiAB® Anti-Hu CD28 FITC [CD28.2]](/web/image/product.product/82752/image_1024/%5BAFG-EXB-1253%5D%20AffiAB%C2%AE%20Anti-Hu%20CD28%20FITC%20%5BCD28.2%5D?unique=d31c23b)
Overview
CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Specificity:
The mouse monoclonal antibody CD28.2 recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
Antigen
CD28
Clone
CD28.2
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide