![AffiAB® Anti-Hu CD264 FITC [TRAIL-R4-01]](/web/image/product.product/82741/image_1024/%5BAFG-EXB-1242%5D%20AffiAB%C2%AE%20Anti-Hu%20CD264%20FITC%20%5BTRAIL-R4-01%5D?unique=d31c23b)
Overview
TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4) .
Specificity:
The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
Antigen
CD264
Clone
TRAIL-R4-01
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide