![AffiAB® Anti-Hu CD263 FITC [TRAIL-R3-02]](/web/image/product.product/82740/image_1024/%5BAFG-EXB-1241%5D%20AffiAB%C2%AE%20Anti-Hu%20CD263%20FITC%20%5BTRAIL-R3-02%5D?unique=d31c23b)
Overview
TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5) .
Specificity:
The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Antigen
CD263
Clone
TRAIL-R3-02
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
TRAIL-R3-hIgGhc fusion protein
Application
FC (QC tested)
Regulatory status
RUO
Concentration
0.1 mg/ml
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide