![AffiAB® Anti-Hu CD98 FITC [MEM-108]](/web/image/product.product/82683/image_1024/%5BAFG-EXB-1184%5D%20AffiAB%C2%AE%20Anti-Hu%20CD98%20FITC%20%5BMEM-108%5D?unique=d31c23b)
Overview
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs) . CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
Specificity:
The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain) . CD98 is expressed on T lymphocytes (upon activation) and activated NK cells; it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets.
Antigen
CD98
Clone
MEM-108
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
RAJI human Burkitt's lymphoma cell line
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide