![AffiAB® Anti-Hu CD97 FITC [MEM-180]](/web/image/product.product/82682/image_1024/%5BAFG-EXB-1183%5D%20AffiAB%C2%AE%20Anti-Hu%20CD97%20FITC%20%5BMEM-180%5D?unique=d31c23b)
Overview
CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.
Specificity:
The antibody MEM-180 recognizes a unique epitope on CD97, a 75-85 kDa surface glycoprotein of G-protein-coupled receptor family, expressed on activated B and T lymphocytes, monocytes/macrophages, dendritic cells and granulocytes.
Antigen
CD97
Clone
MEM-180
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
PHA-activated peripheral blood cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide