![AffiAB® Anti-Hu CD77 FITC [38.13]](/web/image/product.product/82649/image_1024/%5BAFG-EXB-1150%5D%20AffiAB%C2%AE%20Anti-Hu%20CD77%20FITC%20%5B38.13%5D?unique=d31c23b)
Overview
CD77 (globotriaosylceramide Gb3), also known as the Pk blood group antigen, BLA (Burkitt´s lymphoma associated antigen), or CTH (ceramide trihexoside) is a neutral glycosphingolipid composed of three carbohydrate molecules linked to a lipid moiety in the cell membrane (Gal-alpha1-4Gal-beta1-4Glc-beta1-Cer) . It is expressed on germinal center B cells, Burkitt´s lymphoma cells, it can be induced on extrafolicular B cells and it is also found on endothelia and epithelia. CD77 may be involved in elimination of germinal center B cells that fail to produce high affinity antibodies, and serves also as receptor for shiga toxin and verotoxin.
Specificity:
The rat monoclonal antibody 38.13 recognizes CD77 (globotriaosylceramide Gb3), a neutral glycosphingolipid expressed mainly on the surface of B cell populations, such as germinal center B cells and Burkitt´s lymphoma cells.
Antigen
CD77
Clone
38.13
Species Reactivity
Human
Negative Species
N/A
Isotype
Lewis Rat IgM
Immunogen
Daudi cell line (Burkitt´s lymphoma)
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide