![AffiAB® Anti-Hu CD274 FITC [29E.2A3]](/web/image/product.product/82646/image_1024/%5BAFG-EXB-1147%5D%20AffiAB%C2%AE%20Anti-Hu%20CD274%20FITC%20%5B29E.2A3%5D?unique=d31c23b)
Overview
CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its receptor CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor (s) for CD274 is likely.
Specificity:
The mouse monoclonal antibody 29E.2A3 recognizes an extracellular epitope of CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas.
Antigen
CD274
Clone
29E.2A3
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG2b kappa
Immunogen
Full length human CD274
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide