![AffiAB® Anti-Hu CD41/CD61 (PAC-1 epitope) FITC [PAC-1]](/web/image/product.product/82630/image_1024/%5BAFG-EXB-1131%5D%20AffiAB%C2%AE%20Anti-Hu%20CD41-CD61%20%28PAC-1%20epitope%29%20FITC%20%5BPAC-1%5D?unique=d31c23b)
Overview
CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.
Specificity:
The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.
Antigen
CD41/CD61 (PAC-1 epitope)
Clone
PAC-1
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgM kappa
Immunogen
Human platelets
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
FITC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide