![AffiAB® Anti-Hu CD105 Biotin [MEM-229]](/web/image/product.product/82586/image_1024/%5BAFG-EXB-1087%5D%20AffiAB%C2%AE%20Anti-Hu%20CD105%20Biotin%20%5BMEM-229%5D?unique=d31c23b)
Overview
CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Specificity:
The antibody MEM-229 recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Antigen
CD105
Clone
MEM-229
Species Reactivity
Pig, Human
Negative Species
Dog, Horse
Isotype
Mouse IgG2a
Immunogen
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Application
FC (QC tested), WB, IHC (F), ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Biotin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide