![AffiAB® Anti-Hu CD59 Biotin [MEM-43]](/web/image/product.product/82549/image_1024/%5BAFG-EXB-1050%5D%20AffiAB%C2%AE%20Anti-Hu%20CD59%20Biotin%20%5BMEM-43%5D?unique=d31c23b)
Overview
CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC) . It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
Specificity:
The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI) -anchored glycoprotein expressed on the surface of all hematopoietic cells; it is widely present on cells in all tissues. This antibody does not compete with MEM-43/5, and has blocking activity.
Antigen
CD59
Clone
MEM-43
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a
Immunogen
Thymocytes and T lymphocytes
Application
FC (QC tested), IP, IHC (P)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Biotin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide