![AffiAB® Anti-BCL6 APC [IG191E/A8]](/web/image/product.product/79980/image_1024/%5BAFG-EXB-1010%5D%20AffiAB%C2%AE%20Anti-BCL6%20APC%20%5BIG191E-A8%5D?unique=0daa593)
Overview
BCL6 is a zinc finger-containing transcription factor, which acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. On B cells, BCL6 induces proliferation, antibody class switching and affinity maturation, whereas it inhibits their differentiation into plasma cells. On T cells, BCL6 induces their differentiation into T-FH cells.
Specificity:
The mouse monoclonal antibody IG191E/A8 recognizes BCL6, a transcriptional repressor serving as a master regulator of germinal center reaction.
Antigen
BCL6
Clone
IG191E/A8
Species Reactivity
Mouse, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
pCDNA3 plasmid containing full-length sequence of human BCL6
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
APC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide