![AffiAB® Anti-Hu BCL2 APC [Bcl-2/100]](/web/image/product.product/79921/image_1024/%5BAFG-EXB-0951%5D%20AffiAB%C2%AE%20Anti-Hu%20BCL2%20APC%20%5BBcl-2-100%5D?unique=0daa593)
Overview
Bcl2 (B cell chronic lymphatic leukemia protein 2) is a proto-oncogen, which can contribute to tumorigenesis by counteracting apoptosis in various cell types. The anti-apoptotic effect of Bcl2 is performed by its interactions with suppressors and agonists of cell death and under physiological conditions it is regulated by proteolytic processing and phosphorylation. Bcl2 expression can be detected mainly in lymphoid tissues and in the basal cells of epithelial tissues. It is also a marker that can help in classification of lymphoproliferative diseases and in prognostics of some epithelial neoplasms.
Specificity:
The mouse monoclonal antibody Bcl-2/100 recognizes Bcl2, a 26 kDa intracellular protooncogen with anti-apoptotic effect, expressed in outer mitochondrial membrane, endoplasmic reticulum and nuclear envelope.
Antigen
BCL2
Clone
Bcl-2/100
Species Reactivity
Human
Negative Species
Mouse
Isotype
Mouse IgG1
Immunogen
Synthetic peptide corresponding to the amino acids 41-54 of human Bcl2
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
APC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide