![AffiAB® Anti-Hu CD38 APC [HIT2]](/web/image/product.product/79841/image_1024/%5BAFG-EXB-0871%5D%20AffiAB%C2%AE%20Anti-Hu%20CD38%20APC%20%5BHIT2%5D?unique=d31c23b)
Overview
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
Specificity:
The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.
Antigen
CD38
Clone
HIT2
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human thymocytes in foetus
Application
FC (QC tested)
Regulatory status
RUO
Concentration
N/A
Format
APC
Storage / Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide