![AffiAB® Anti-Hu CD266 Purified Low Endotoxin [ITEM-4]](/web/image/product.product/79760/image_1024/%5BAFG-EXB-0790%5D%20AffiAB%C2%AE%20Anti-Hu%20CD266%20Purified%20Low%20Endotoxin%20%5BITEM-4%5D?unique=d31c23b)
Overview
CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Specificity:
The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Antigen
CD266
Clone
ITEM-4
Species Reactivity
Mouse, Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
human CD266-transfected P815 cells
Application
FC (QC tested), WB, IHC (F), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4