![AffiAB® Anti-Hu CD85j Purified Low Endotoxin [GHI/75]](/web/image/product.product/79756/image_1024/%5BAFG-EXB-0786%5D%20AffiAB%C2%AE%20Anti-Hu%20CD85j%20Purified%20Low%20Endotoxin%20%5BGHI-75%5D?unique=d31c23b)
Overview
CD85j, also known as ILT-2 (Ig-like transcript 2), LIR-1 (leukocyte Ig-like receptor 1), or LILRB1 (leukocyte Ig-like receptor B1), is a member of Ig superfamily transmembrane glycoproteins named CD85. The CD85j protein is expressed on several types of immune cells (plasma cells, B cells, monocytes, T and NK cell subsets) where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
Specificity:
The mouse monoclonal antibody GHI/75 recognizes an extracellular epitope of CD85j / ILT2, an 110-120 kDa membrane glycoprotein expressed strongly on plasma cells, moderately on circulating B cells, and weakly on monocytes. It is also expressed on T cell and NK cell subsets (variable, individual) .
Antigen
CD85j
Clone
GHI/75
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b kappa
Immunogen
Hairy cell leukaemia cells
Application
FC (QC tested), IP, WB, FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4