![AffiAB® Anti-Ms CD80 Purified Low Endotoxin [16-10A1]](/web/image/product.product/79733/image_1024/%5BAFG-EXB-0763%5D%20AffiAB%C2%AE%20Anti-Ms%20CD80%20Purified%20Low%20Endotoxin%20%5B16-10A1%5D?unique=d31c23b)
Overview
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152) . The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Specificity:
The Armenian hamster monoclonal antibody 16-10A1 reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Antigen
CD80
Clone
16-10A1
Species Reactivity
Mouse, Dog
Negative Species
N/A
Isotype
Armenian Hamster IgG2
Immunogen
CD80-transfected CHO cell line
Application
IHC (F), IP, FC (QC tested), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4