![AffiAB® Anti-Ms CD19 Purified Low Endotoxin [1D3]](/web/image/product.product/79724/image_1024/%5BAFG-EXB-0754%5D%20AffiAB%C2%AE%20Anti-Ms%20CD19%20Purified%20Low%20Endotoxin%20%5B1D3%5D?unique=d31c23b)
Overview
CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Specificity:
The rat monoclonal antibody 1D3 detects an extracellular epitope of murine CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Antigen
CD19
Clone
1D3
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Rat IgG2a
Immunogen
Mouse CD19-transfected cell line
Application
FC (QC tested), IP, IHC (F), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4