![AffiAB® Anti-Hu CD253 Purified Low Endotoxin [2E5]](/web/image/product.product/79703/image_1024/%5BAFG-EXB-0733%5D%20AffiAB%C2%AE%20Anti-Hu%20CD253%20Purified%20Low%20Endotoxin%20%5B2E5%5D?unique=d31c23b)
Overview
Human CD253 / TRAIL (TNF-related apoptosis inducing ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2) .
Specificity:
The antibody 2E5 reacts with an extracellular epitope within C-terminal half of TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
Antigen
CD253
Clone
2E5
Species Reactivity
Human
Negative Species
Mouse
Isotype
Mouse IgG1
Immunogen
Recombinant soluble fragment (aa 95-281) of human TRAIL.
Application
FC (QC tested), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4