![AffiAB® Anti-Hu CD279 Purified Low Endotoxin [EH12.2H7]](/web/image/product.product/79691/image_1024/%5BAFG-EXB-0721%5D%20AffiAB%C2%AE%20Anti-Hu%20CD279%20Purified%20Low%20Endotoxin%20%5BEH12.2H7%5D?unique=d31c23b)
Overview
CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
Specificity:
The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.
Antigen
CD279
Clone
EH12.2H7
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
recombinant human CD279
Application
FC (QC tested), IHC (F), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Low Endotoxin
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4