![AffiAB® Anti-Hu CD207 Purified [2G3]](/web/image/product.product/79681/image_1024/%5BAFG-EXB-0711%5D%20AffiAB%C2%AE%20Anti-Hu%20CD207%20Purified%20%5B2G3%5D?unique=d31c23b)
Overview
CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.
Specificity:
The mouse monoclonal antibody 2G3 recognizes an extracellular/luminal epitope of CD207, a transmembrane protein selectively expressed by Langerhans cells and by some other dendritic cell subsets. This antibody clone can target vaccine-peptides to dendritic cells.
Antigen
CD207
Clone
2G3
Species Reactivity
Human, Non-human primates
Negative Species
N/A
Isotype
Mouse IgG1 lambda
Immunogen
Fusion protein of human CD207 extracellular part and IgG Fc fragment
Application
ICC, FC (QC tested), ELISA, IHC (F)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide