![AffiAB® Anti-Hu HER3 Purified [H3Mab-17]](/web/image/product.product/79640/image_1024/%5BAFG-EXB-0670%5D%20AffiAB%C2%AE%20Anti-Hu%20HER3%20Purified%20%5BH3Mab-17%5D?unique=06fe5f0)
Overview
HER3 (ERBB3) is a transmembrane protein of the epidermal growth factor receptor family, although it does not have an active tyrosine kinase domain. It can bind its ligand, but for further signaling it needs heterodimerization with other receptor tyrosine kinases of EGFR family. Overexpression of HER3 has been observed in many carcinomas. Activity of HER3 can be modulated by one of its isoforms, that is secreted from the cell, as its lacks the transmembrane domain.
Specificity:
The mouse monoclonal antibody H3Mab-17 recognizes an extracellular epitope on human HER3, a member of EGFR family of receptor tyrosine kinases, which is overexpressed in many cancers.
Antigen
HER3
Clone
H3Mab-17
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a kappa
Immunogen
HER3-transfected CHO cells
Application
FC (QC tested)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide