![AffiAB® Anti-Hu PODXL Purified [PcMab-47]](/web/image/product.product/79638/image_1024/%5BAFG-EXB-0668%5D%20AffiAB%C2%AE%20Anti-Hu%20PODXL%20Purified%20%5BPcMab-47%5D?unique=06fe5f0)
Overview
PODXL is a highly glycosylated sialomucin, which is expressed in many types of tumors, as well as it is a well known marker of embryonic stem cells. Overexpression of PODXL is an independent predictor of cancer progression, metastasis, and poor outcome. PODXL promotes tumor growts and invasiveness, and is a potential target for antibody therapy.
Specificity:
The mouse monoclonal antibody PcMab-47 recognizes a glycosylation-dependent epitope (aa 207-210) on human PODXL, a highly glycosylated transmembrane glycoprotein expressed above all in many types of cancer tissues, and on embryonic stem cells.
Antigen
PODXL
Clone
PcMab-47
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
recombinant PODXL ectodomain
Application
WB, FC (QC tested), IHC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide