![AffiAB® Anti-PPM1D Purified [7E11/C5]](/web/image/product.product/79635/image_1024/%5BAFG-EXB-0665%5D%20AffiAB%C2%AE%20Anti-PPM1D%20Purified%20%5B7E11-C5%5D?unique=06fe5f0)
Overview
PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.
Specificity:
The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D, a protein phosphatase, which contributes to development of some carcinomas.
Antigen
PPM1D
Clone
7E11/C5
Species Reactivity
Mouse, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Purified human PPM1D
Application
WB, IHC (P), ICC, ELISA
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide