![AffiAB® Anti-Galectin-3 Purified [M3/38]](/web/image/product.product/79618/image_1024/%5BAFG-EXB-0648%5D%20AffiAB%C2%AE%20Anti-Galectin-3%20Purified%20%5BM3-38%5D?unique=06fe5f0)
Overview
Galectin-3 is a galactose-binding lectin, which modulates intercellular interactions and interactions of the cell with ECM, as well as it is a nuclear protein and a component of inner mitochondrial membrane. Galectin-3 binds IgE, and takes part in formation of immunological synapse. It is detected cytoplasmatically in adenomas and carcinomas by immunohistochemistry. It is expressed in colonic and intestinal epithelium, papillary and follicular carcinomas, neoplastic astrocytes, inflammatory macrophages, and some lymphocytes. Upregulation of galectin-3 is involved in cancer progression and metastasis.
Specificity:
The rat monoclonal antibody M3/38 recognizes an epitope within amino acids 40-100 in N-terminal domain of murine galectin 3, a 35 kDa lectin expressed both intracellularly, and after its secretion also on the cell surface.
Antigen
Galectin-3
Clone
M3/38
Species Reactivity
Human, Mouse
Negative Species
N/A
Isotype
Rat IgG2a kappa
Immunogen
murine galectin-3
Application
WB, IHC (P), ICC, FC (QC tested), IP
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide