![AffiAB® Anti-Hu CD126 Purified [UV4]](/web/image/product.product/79614/image_1024/%5BAFG-EXB-0644%5D%20AffiAB%C2%AE%20Anti-Hu%20CD126%20Purified%20%5BUV4%5D?unique=d31c23b)
Overview
CD126 is a type I plasma membrane glycoprotein of the hematopoietin receptor superfamily. It binds IL-6 and then associates with CD130 homodimers to form the functional IL-6 receptor. CD126 alone binds IL-6 with low affinity, and after association with CD130 with high affinity. It is expressed on normal B cells, T cells, monocytes, and hepatocytes, as well as on neoplastic (but not on normal) plasma cells. It is being used as an endothelial marker for separation of circulating endothelial cells from blood.
Specificity:
The mouse monoclonal antibody UV4 recognizes an extracellular epitope of CD126, a transmembrane glycoprotein serving as IL-6 receptor.
Antigen
CD126
Clone
UV4
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
human myeloma U266 cells
Application
WB, FC (QC tested), IP
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide