![AffiAB® Anti-CD325 Purified [8C11]](/web/image/product.product/79595/image_1024/%5BAFG-EXB-0625%5D%20AffiAB%C2%AE%20Anti-CD325%20Purified%20%5B8C11%5D?unique=d31c23b)
Overview
CD325 (N-cadherin) is a type I transmembrane protein, which forms a complex with catenins, that is linked to the actin cytoskeleton. This complex is important in synapses and for functional plasticity of neurons, and is also essential for embryonic development. Decreased CD325 cleavage caused by mutations in presenilin 1 is associated with Alzheimer´s disease. Besides nervous system, CD325 is expressed on the surface of malignant T cells, and increases their adhesion to epithelia, as well as their ability to invade and metastasize to inflammatory sites.
Specificity:
The mouse monoclonal antibody 8C11 recognizes an extracellular epitope of CD325 (N-cadherin), a transmembrane protein associated with actin cytoskeleton system, which is expressed mainly by neurons, osteoblasts, endothelial cells, and stem cells.
Antigen
CD325
Clone
8C11
Species Reactivity
Mouse, Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
bacterially expressed extracellular domain of human CD325
Application
WB, ICC, FC (QC tested), IHC, IP
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide