![AffiAB® Anti-HDAC6 Purified [178]](/web/image/product.product/79591/image_1024/%5BAFG-EXB-0621%5D%20AffiAB%C2%AE%20Anti-HDAC6%20Purified%20%5B178%5D?unique=06fe5f0)
Overview
Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.
Specificity:
The mouse monoclonal antibody 178 recognizes zinc finger domain of human histone deacetylase 6 (HDAC6; an intracellular antigen) . Crossreactivity with other species was not tested.
Antigen
HDAC6
Clone
178
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
human HDAC6
Application
ICC, ELISA, IP
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide