![AffiAB® Anti-Perforin Purified [dG9]](/web/image/product.product/79529/image_1024/%5BAFG-EXB-0559%5D%20AffiAB%C2%AE%20Anti-Perforin%20Purified%20%5BdG9%5D?unique=06fe5f0)
Overview
Perforin is a 70 kDa cytolytic protein with structural and functional similarities to complement component 9 (C9) . It is stored in cytoplasmic granules of cytotoxic T cells and NK cells and after its release it forms transmembrane pores in the target cells to kill it. As perforin is a key effector molecule for cell-mediated cytolysis, defects of its gene can cause severe disorders.
Specificity:
The mouse monoclonal antibody dG9 (also known as deltaG9) recognizes perforin, a 70 kDa protein expressed in cytoplasmic granules of cytotoxic T cells and NK cells.
Antigen
Perforin
Clone
dG9
Species Reactivity
Human, Cow
Negative Species
Mouse
Isotype
Mouse IgG2b kappa
Immunogen
purified granules from human YT lymphoma cell line
Application
FC (QC tested), IP, IHC (P), IHC (F), ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide