![AffiAB® Anti-Hu CD116 Purified [4H1]](/web/image/product.product/79525/image_1024/%5BAFG-EXB-0555%5D%20AffiAB%C2%AE%20Anti-Hu%20CD116%20Purified%20%5B4H1%5D?unique=d31c23b)
Overview
CD116 (GM-CSF R alpha) is the low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) . CD116 heterodimerizes with CD131, the common beta chain subunit shared with IL-3 and IL5- receptors, to form the high affinity GM-CSF receptor. CD116 is expressed by myeloid cells including macrophages, neutrophils, eosinophils, dendritic cells, and their precursors, as well as on endothelial cells. It is being used as a specific marker of myeloid leukemias.
Specificity:
The mouse monoclonal antibody 4H1 recognizes an extracellular epitope of human CD116, the GM-CSF receptor alpha subunit (approx. 80 kDa) expressed e.g. by neutrophils, eosinophils, monocytes and macrophages.
Antigen
CD116
Clone
4H1
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1 kappa
Immunogen
CD116-transfected COS cells
Application
FC (QC tested), IP, WB, IHC (F), MC (CyTOF)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide