![AffiAB® Anti-Hu CD178 Purified [NOK-1]](/web/image/product.product/79520/image_1024/%5BAFG-EXB-0550%5D%20AffiAB%C2%AE%20Anti-Hu%20CD178%20Purified%20%5BNOK-1%5D?unique=d31c23b)
Overview
CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE) . CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.
Specificity:
The mouse monoclonal antibody NOK-1 recognizes an extracellular epitope of CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.
Antigen
CD178
Clone
NOK-1
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
L5178Y mouse T lymphoma cells expressing recombinant human CD178
Application
FC (QC tested), IP, WB, ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide