![AffiAB® Anti-NR2F6 Purified [EM-51]](/web/image/product.product/79492/image_1024/%5BAFG-EXB-0522%5D%20AffiAB%C2%AE%20Anti-NR2F6%20Purified%20%5BEM-51%5D?unique=06fe5f0)
Overview
NR2F6 (nuclear receptor subfamily 2 group F member 6), also known as EAR2 or ERBAL2, is a transcription factor involved in modulation of hormonal responses. NR2F6 represses e.g. transcription of the oxytocin-neurophysin gene, renin gene, lutropin-choriogonadotropic hormone receptor gene, and the thyroid hormone receptor gene. In the immune system, NR2F6 affects IL-17 expression in the Th-17 cells, thus also the balance between immunological tolerance and autoimmunity.
Specificity:
The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor (intracellular antigen) expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations.
Antigen
NR2F6
Clone
EM-51
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a kappa
Immunogen
Recombinant human NR2F6 protein expressed in E. coli
Application
WB, FC (IC)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide