![AffiAB® Anti-TFG Purified [TFG-03]](/web/image/product.product/79482/image_1024/%5BAFG-EXB-0512%5D%20AffiAB%C2%AE%20Anti-TFG%20Purified%20%5BTFG-03%5D?unique=06fe5f0)
Overview
TFG (TRK-fused gene protein) is a regulatory protein with not fully understood function. Its defects are associated with various carcinomas, such as e.g. melanoma, thyroid papillary carcinoma, or glioma. TFG structure (multiple protein interaction motifs) indicated it can be an adaptor protein. It has been demonstrated TFG interacts with proteins modulating the NFkappaB pathway (TANK and NEMO) . TNG enhances the effect of TNFalpha, TANK, TRAF2 and TRAF6 in inducing NFkappaB activity.
Specificity:
The mouse monoclonal antibody TFG-03 recognizes TFG, an approximately 50 kDa intracellular protein with regulatory functions.
Antigen
TFG
Clone
TFG-03
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
Human recombinant protein Trx-his-NTFG
Application
IP, WB, ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide