![AffiAB® Anti-ABRA1 Purified [ABRA1-01]](/web/image/product.product/79407/image_1024/%5BAFG-EXB-0437%5D%20AffiAB%C2%AE%20Anti-ABRA1%20Purified%20%5BABRA1-01%5D?unique=1da554d)
Overview
ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Specificity:
The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
Antigen
ABRA1
Clone
ABRA1-01
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG
Immunogen
Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Application
IP, WB, FC (IC)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide