![AffiAB® Anti-PRR7 Purified [TRAP3/10]](/web/image/product.product/79405/image_1024/%5BAFG-EXB-0435%5D%20AffiAB%C2%AE%20Anti-PRR7%20Purified%20%5BTRAP3-10%5D?unique=1da554d)
Overview
PRR7/TRAP3 (proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein ubiquitously expressed at low level (most in brain) . Its amino acid sequence is extremely conserved among mammalian and other species. PRR7/TRAP3 contains potential palmitoylation motif and is found in lipid rafts. It is a part of the complex postsynaptic density fraction in neurons and associates with PSD-95, NMDA receptor and probably other proteins. The intracellular domain of PRR7/TRAP3 contains several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif. So far nothing is known about function of this protein. It may be involved in regulation of some receptor signaling and in formation of neurologic and immunologic synapse.
Specificity:
The mouse monoclonal antibody TRAP3/10 recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126-253 of human PRR7 / TRAP3), a 28 kDa proline-rich membrane protein presumably associated with NMDA receptor complex.
Antigen
PRR7
Clone
TRAP3/10
Species Reactivity
Human, Mouse, Rat
Negative Species
N/A
Isotype
Mouse IgG2a
Immunogen
Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
Application
WB, ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide