![AffiAB® Anti-GRB2 Purified [PAb (554) ]](/web/image/product.product/79365/image_1024/%5BAFG-EXB-0395%5D%20AffiAB%C2%AE%20Anti-GRB2%20Purified%20%5BPAb%20%28554%29%20%5D?unique=1da554d)
Overview
Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
Specificity:
The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa intracellular adaptor protein. The immunogen has 100% identity between man, cow, rat and mouse.
Antigen
GRB2
Clone
PAb (554)
Species Reactivity
Human
Negative Species
N/A
Isotype
Rabbit polyclonal
Immunogen
Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217) .
Application
WB
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Stabilizing phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide